Investigation of mode of action of product for perineal wound repair

PPR Healthcare have carefully developed and formulated their products to be as effective and impactful as possible for wound healing. As part of this process, research and development is key and PPR Healthcare engaged with Shannon ABC to help validate the mode of action of the PPR Healthcare product. Several different cell types are involved in the wound healing process. A type of a cell called a macrophage plays multiple roles in wound healing. In the early wound state:

• Macrophages release chemicals that promote the inflammatory response
• Inflammation is a normal part of the wound-healing process
• Macrophages are responsible for inducing and clearing dead cells paving the way for the resolution of inflammation
• As macrophages clear these dead cells, they undergo a change to a reparative state that stimulates cells and processes that promote tissue regeneration.

In this way, macrophages promote the transition to the proliferative phase of healing. PPR healthcare wanted to determine how their product impacted this complex biological process.